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The distinct mode of CTR and AMYR engagement by Cagri revealed in the current study, together with the correlated distinctions in functional responses at individual receptors, is likely to be important in the differentiated, high efficacy, of Cagri as a first-in-class obesity drug in both preclinical animal models and in treatment of obese patients in clinical trials 2,3,4

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Structure of lutein and zeaxanthin The hydroxyl group of xanthophyll contributed to their polarity during its absorption, metabolism, distribution, and uptake into body tissues [22]