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Emerging evidence indicates that riboflavin deficiency skews microglia toward a pro-inflammatory M1 phenotype, characterized by elevated iNOS, IL-1, and TNF-, whereas riboflavin supplementation promotes an anti-inflammatory M2 phenotype, with higher IL-10 and TGF- expression via STAT6 activation (67, 68)

Oncotarget 7, 7463074647

FACT 3 OF 6 IM injections for severe deficiency or absorption failure If your sublingual dose doesnt maintain serum B12 above 400 pg/mL, switch to intramuscular injections: 1,000 mcg monthly (more often initially if very deficient)

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