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The shifts are per-endpoint, not a single multiplier

Chen H, Huang X, Dong M, Wen S, Zhou L, Yuan X

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The health outcomes range from increased risk of premature death to serious chronic conditions that reduce the overall quality of life [1]

Realistically, you're looking at 3 months before you'd see early signs of response, and 6 months for a meaningful assessment

Vitamin B12 plays a role in DNA synthesis and red blood cell formation