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As shown for GLP-1RAs, the discovery of pleiotropic effects can effectively extend the lifespan and markets of drugs by facilitating repurposing

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It is reported that serum of patients that were administered garlic extract with standard antituberculosis had increased antitubercular activity compared to the control group, suggesting a synergistic effect when garlic is given in combination with antituberculosis drugs (Gupta et al., 1999)

For example, glucose deprivation induces rapid NADPH depletion, promoting ferroptosis-mediated oxidative stress and cell death [16]

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The Genetic Switch: Understanding Nrf2 Activation If glutathione is conceptualized as the primary fuel of the cellular antioxidant system, a crucial question concerns the regulatory engine that governs its synthesis and utilization