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Early weight loss responders to liraglutide 3.0 mg achieved greater weight loss and regression to normoglycaemia, and reduced development of T2D at 3 years, versus early nonresponders in the SCALE obesity and prediabetes trial [abstract]

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A study by Mitchell et al used a surgically implanted intracranial pressure (ICP) monitor and showed reduction in ICP within minutes to hours after GLP-1 RA initiation long before weight loss would have occurred

Some patients experience persistent gastrointestinal side effects that may limit long-term tolerability

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