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Metabolic analysis revealed that the source of the anti-ferroptosis effect of GCH1-overexpressing cells was BH4/BH2, supplementation with which rescued cell viability

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The efficacy of high-dose celecoxib (800/400 mg) was comparable to that of indomethacin (50 mg tid)

Structurally, its total contact surface area (2.08 nm 2 ) exceeds that of sitagliptin (1.90 nm 2 ), suggesting tighter binding to the S2 extensive subsite via enhanced hydrophobic interactions mediated by the anchor lock domain

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