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Inhibition of c-Met with PF2341066 and siRNA decreases EGF-induced phenotypes of invasion by 86% and motility by 81%, suggesting that a novel form of c-Met activation is utilized by EGFR to maximize these biological effects

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If a patient has a dominance of PGE-2, vasodilatation of major arteries with spasm of collateral circuits would be expected, which in turn can cause pain