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The SURMOUNT-1 trial randomized 2500 obese prediabetics to tirzepatide or placebo

By directly acting on appetite circuits in the brain, GLP-1 may cause people to experience less hunger

(2) nuclear translocation of NF-B

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Video abstract Similar content being viewed by others 1 Introduction The principal goal of disease management in type 2 diabetes (T2D) is the prevention or delay of both microvascular and macrovascular complications through the achievement of good glycemic control and, where necessary, weight loss and cardiovascular (CV) risk factor management [1]

This dual mechanism distinguishes it from traditional GLP-1 therapies, which target only the GLP-1 pathway