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Work on endogenous morphine and nitric oxide has suggested that morphinergic signaling can influence mitochondrial oxygen consumption, redox behavior, permeability transitions, and overall respiratory tone through nitric oxide-dependent processes [8,12-14]

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Although clinical research on GLP-1RAs in SIM is still limited, some preliminary evidence (135,145) supports the improvement of muscle mass and function by GLP-1 analogs

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Gastroparesis and pulmonary aspiration risk GLP-1R agonists delay gastric emptying , leading to concerns about residual gastric content at the time of anaesthesia