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Nat Rev Immunol 2:195-204, 2002

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Synthesis of chitosan and glutathione-chitosan nanocomposite Chitosan NPs were synthesized using the ionotropic gelation method, following a procedure similar to the one described by Ayodele et al

The IDO inhibitors are in development for use in overcoming the resistance to immunotherapies targeting immune checkpoints, thus supporting combination therapies

Glutathione helps reduce hyperpigmentation by the following mechanism: By reducing melanogenesis by direct inactivation of tyrosinase activity (the key enzyme of melanogenesis by binding with the copper-containing active site of the enzyme)