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doi: 10.1038/nature00887

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The optimal timing for oral glutathione is 12 hours before drinking begins (to pre-load hepatic reserves), immediately before bed (to support overnight acetaldehyde clearance), and upon waking (to address residual oxidative stress)

Explanations for this excess of men have been attributed to possible protective hormonal factors in women, the increased likelihood of men being exposed to putative risk factors, and the under recognition of older women in some population registries (Wijesekera and Leigh 2009)

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