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They found a half-life of under 30 minutes post-injection, with bioavailability after intramuscular administration at 14 to 19 percent for rats and 45 to 51 percent for dogs

For gastrointestinal conditions specifically, some clinicians use oral capsules, since the peptide acts directly on the gut lining

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Conditions that reduce hepatic blood flow (congestive heart failure, portal hypertension, liver metastases compressing hepatic vasculature) can unexpectedly increase drug exposure even at standard doses