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ROO primarily targets the polyunsaturated fatty acids (PUFA) found in DNA bases and cell membranes, but it also targets almost all important groups of biomolecules

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Nature 508(7494):103107 Chen XL, Fu JP, Shi J, Wan P, Cao H, Tang ZM (2015) CXC195 induces apoptosis and endoplastic reticulum stress in human hepatocellular carcinoma cells by inhibiting the PI3K/Akt/mTOR signaling pathway

We further characterized these TCEs in vitro and in vivo, showing these constructs achieve tumor killing across multiple tumor cell types with high fM - low pM EC 50 and drive robust cytokine production