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As mentioned above, within the IMM, cytochrome c participates in the mitochondrial ETC, using its heme group as a redox intermediate to shuttle electrons between complex III and complex IV

In line with the animal studies, LCA supplementation induced a decrement of PA-induced oxidative stress (Decreased cellular MDA) and enhanced corresponding anti-oxidative system (Restored NRF2/SOD2 signaling) in primary atrial cardiomyocytes

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Hight et al., 1998