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Collagen turnover, skin barrier integrity, and fibroblast activity vary based on age, genetics, and inflammatory state

Phase 2 trial (NEJM 2023) used a structured ramp to 12 mg/week but at trial doses of 8 mg and 12 mg, dropout from gastrointestinal events was substantial

It included subjects with NAFLD, who were or were not obese, and evaluated if, and how, their plasma amino acids were altered, and the relationship with insulin resistance

This minimum requirement becomes the de facto standard

It should be as clear as water

Gross MI, Demo SD,Dennison JB, Chen L, Chernov-Rogan T, Goyal B, Janes JR, Laidig GJ,Lewis ER,Li J