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Oct 5 2020;25(19)doi:10.3390/molecules25194554 Shojaei-Zarghani S, Rafraf M
10.1186/1476-9255-3-1 J Inflamm
Correspondingly, combined treatment with sertraline, an inhibitor of serine/glycine conversion, and radiotherapy significantly impairs the proliferation, clonogenicity and stem cell self-renewal capacity of NSCLC cells, and also effectively suppresses tumor growth in in vivo experiments ( 4.1.2 Colorectal cancer Genes involved in the SSP are generally highly expressed in colorectal cancer and are correlated with unfavorable patient prognosis ( Meanwhile, activation of the Wnt pathway in turn promotes the transcription of SHMT2, forming a positive feedback loop of the SHMT2Wnt/-catenin axis that further strengthens the metabolic output of the SSP ( Clinical samples have confirmed that approximately 82% of OXPHOS-deficient colorectal cancer tissues harbor mtDNA mutations, and the SSP activity in these tumors is significantly higher than that in normal tissues ( The transcription factor FOXC1 has also been shown to reprogram serine metabolism under serine-deprived conditions to promote colorectal cancer proliferation and 5-fluorouracil resistance
10.1186/s10194-019-1064-2 J
its molecules are located between cells, which play a major role in cell functioning in addition to providing skin structure
What makes it bacteriostatic
