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Through MAMs, Ca 2+ can enter mitochondria to maintain mitochondrial homeostasis (139)

Glutathione protects your mitochondria, ensuring your cells are able to make the energy your body needs

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The p62/SQSTM1 (sequestosome 1) protein, which acts as a cargo receptor for autophagic degradation of ubiquitinated proteins, is up-regulated by various stressors

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Conversely, rare non-functioning mutations in ALPL cause a genetic condition called hypophosphatasia, which in addition to high levels of pyrophosphate, causes high levels of P5P.[ref] Peripheral Neuropathy and Vitamin B6: Vitamin B6 deficiency is one of the more common causes of peripheral neuropathy.[ref][ref] On the other hand, excess consumption of vitamin B6 supplements for longer periods (months to years) has caused neuropathy or movement disorders in a few individuals