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Mechanistic insights also reveal that GLP-1RAs modulate inflammasome activity, specifically the NLRP3 inflammasome, thus reducing pyroptosis and inflammatory cell death in hepatic and immune cells (29)

Unlike TRANSCEND-T2D-1, which specifically targeted a diabetes population, TRIUMPH-2 is a weight management basket trial where participants also have T2D a distinct enrollment design

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Both medications show similar side effect profiles, though individual response to each can vary significantly

For many, tirzepatide is more than a treatment

1 WeightWatchers offers a GLP-1 companion programme in the UK