Experimental investigations have demonstrated that cholangiocytes are sensitive to GLP-1 and respond with augmented proliferation, potentially increasing the risk of duct obstruction [47,48]
It takes only minutes to prepare and its GLP-1 friendly
For the efficacy estimand, the LSM change in HbA1c from baseline at week 52 as the primary endpoint was 2.24%, 2.43%, and 2.58% with tirzepatide 5, 10, and 15 mg, respectively, versus 1.44% with insulin glargine
doi:10.1111/j.1467-789X.2006.00270.x 86
Your body naturally produces GLP-1 in your gut with receptor sites all over your body- brain, bone, blood vessels, heart, and many other places throughout your body
They lose lean muscle mass and regain the weight, risking conditions like sarcopenic obesity, leaving them potentially worse off than before they started the medication