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Why rebound happens Metabolic adaptation Long-term weight maintenance is difficult partly because energy expenditure often drops more than expected after weight loss, a phenomenon known as adaptive thermogenesis, and that reduced expenditure can persist while weight is suppressed

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GLP-1 medications have been found to reduce inflammatory markers in the body, lowering the risk of developing metabolic syndrome-related diseases

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After this point, you'll start to see a gradual decline in its efficacy