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While some are optimistic that it will expand access to GLP-1 drugs for weight loss, others doubt the Trump administration will be able to negotiate lower prices than the insurance companies approved to offer Medicare Part D plans can and question how many state Medicaid agencies will choose to participate, given the long-term budget exposure associated with chronic use of high-cost drugs

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2.9 Heart Failure: Some studies have raised concerns about a potential increased risk of heart failure associated with DPP - 4 inhibitors particularly with Saxagliptin