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Upon amino acid deprivation, it is established that uncharged transfer RNAs (tRNAs) triggers an adaptive integrated stress response, termed amino acid response (AAR), which activates the expression of stress-responsive transcription factor ATF4 45,46

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is part of a clinical trial data-sharing consortium that facilitates access for qualified researchers to selected anonymized clinical trial data

doi: 10.1016/j.mam.2017.06.002 78 LueddeM.WinklerT.HeinsenF