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In erythrocytes, the absence of S1P-degrading enzymes allows these cells to produce and store substantial amounts of S1P (Ogawa et al., 2003

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Consequently, single-modality biomarkers frequently fail to generalize because they are sensitive to context (cycle phase, progesterone exposure timing, stimulation protocols, and tissue/cell-type composition), so an apparent signal in one layer may reflect unmeasured confounding rather than functional competence [447]