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In the Phase 3 REDEFINE 1 trial, cagrilintide monotherapy achieved 11.8% average weight loss over 68 weekscomparable to semaglutide but with a notably lower incidence of nausea and vomiting, making it a potential option for patients who dont tolerate GLP-1 medications well
Poudel, D., George, M
However, other studies have demonstrated positive associations between gluteofemoral SAT and IS in humans, including a slower rate of lipolysis, a lower proinflammatory response, and increased secretion of insulin-sensitizing adipokines [30]
When Bloating Signals a Need to Contact Your Provider Mild bloating, mild gas, and a sensation of fullness are expected and manageable
Nature 425 , 516521, doi: 10.1038/nature01991 (2003)