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Beyond gastrointestinal effects, the following safety signals and class-relevant cautions warrant attention: Heart rate elevation: Retatrutide's glucagon receptor agonism has been associated with modest increases in resting heart rate in Phase 2 data

Nausea is the most common complaint, reported by approximately 44% of users in clinical trials

In the first effort to furnish these answers, we used cardiac functional and coronary perfusion analysis to characterize the effects of semaglutide therapy

Rare cases of muscle weakness or cramps

Overall psychiatric safety Large analyses have not shown an overall increase in psychiatric adverse events with GLP-1 receptor agonists and some data suggest improvements in emotional eating and restrained eating behaviors

doi: 10.1097/JGP.0b013e31822001c1 22 CabouC.BurcelinR