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GLP-1 is also secreted by -cells of the pancreas and the central nervous system (CNS)

Staal FJ, Ela SW, Roederer M, Anderson MT & Herzenberg LA (1992): Glutathione deficiency and human immunodeficiency virus infection

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Tirzepatide is initiated at 2.5 mg weekly (a sub-therapeutic dose intended only for GI adaptation) and escalated by 2.5 mg every 4 weeks to the target dose of 5, 10, or 15 mg