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In patients with Hashimoto's disease, optimization of thyroid hormone replacement with levothyroxine represents the foundational therapeutic step before considering additional weight management strategies

Insulinotropic activity upon oral intake of small molecules has been reported in vivo with cynomolgus monkeys for LY3502970 and PF-06882961, and with humanized GLP-1 receptor mice for TT-OAD2

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Continuing through this plateau typically leads to resumed improvement

Commonly reported side effects may include: Mild to moderate nausea Occasional vomiting or constipation Fatigue or headache in the early stages Appetite suppression, which is intended but can be dramatic for some users These effects are typically temporary and tend to subside as your body adjusts to the medication

Science does not yet have the answers