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doi: 10.1016/j.smim.2006.04.006 135 SmulskiCREibelH

At least it is known that the effect is relatively unaffected by either H507Y or R516A

reconstituted vials must be maintained under constant refrigeration at 2C to 8C

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Interestingly, serum biomarkers of nitric oxide metabolism were found to predict response to sapropterin treatment in children with ASD ( 4 supplementation may be specific to its effect on nitric oxide metabolism

Reconstitution should be performed using approved diluents, following exact dilution ratios to ensure accurate dosing