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These typically resolve without intervention

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A novel and increasingly studied structure in this context is the primary cilium, a microtubule-based organelle that functions as a signaling hub for pathways including Sonic Hedgehog (Shh), Wnt/Wingless, and mechanistic target of rapamycin (mTOR)

Regarding avian/fish model limitations, we incorporated human clinical data on biomarkers, microbiome profiling, and liver disease outcomes to enhance translational relevance

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