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Yoo SE, Chen L, Na R, Liu Y, Rios C, Van Remmen H et al

After glycocalyx degradation, the barrier function of endothelial cells is impaired, further aggravating systemic microcirculatory disorders and organ hypoperfusion [66,67,68]

10.1016/j.canlet.2004.09.041 36 EsatbeyogluT.HuebbeP.ErnstI

However, the complexity of human brain injury and the limitations of animal models in predicting human neurological outcomes require extensive clinical validation before considering these applications

Amylin analogs like cagrilintide work through the area postrema and nucleus tractus solitarius in the brainstem, a region that processes satiety signals through a completely separate neuronal network