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Discontinuation is typically driven by lack of perceived benefit, cost considerations, or completion of a defined protocol cycle rather than safety concerns

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There is no known cause of perioral dermatitis, but overuse of topical corticosteroids is associated with the condition

Scar tissue from repeated injections in the exact same spot can reduce GHK-Cu absorption by creating a fibrous pocket that slows capillary uptake

There are anecdotal reports of adverse effects such as injection site pain, anxiety, insomnia, headaches, dizziness, and gastrointestinal discomfort, but these are not well-documented in clinical studies