NEJM 2023: 10.1056/NEJMoa2301972 Phase 2 dose-response (1, 4, 8, 12 mg arms, 48 wk, non-diabetic obesity)
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Synthesis and characterisation of the N-terminal acetylated 17 to 23 fragment of thymosin beta-4 identified in TB-500
That yields 2.5 mg/mL, which means 0.1 mL on a 1 mL insulin syringe (10 units on a U-100 scale) delivers 250 mcg
Higher ("pharmacologic") doses are required to produce significant acceleration of growth in these conditions, producing blood levels well above normal ("physiologic")
Gentle swirling over 10 to 15 minutes solves most slow-dissolving cases