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Studies have demonstrated that progesterone facilitates GLUT1 expression by binding to progesterone receptor (PGR) and targeting downstream insulin receptor substrate 2 (IRS2), leading to downstream activation of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3 kinase (PI3K/AKT) pathways, which critically support the human endometrial decidualization process to facilitate pregnancy (1618)

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This is why maternal health researchers have put so much work into educating on the importance of preconception, prenatal, and postpartum nutrition

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First, most cell replacement strategies require systemic immunosuppression to prevent both allograft rejection and recurrence of autoimmunity [111]