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Hepatic gene expression analysis also revealed that sterol regulatory elementbinding transcription factor 1 ( Srebf1 ) mRNA expression was significantly upregulated in HFHC-fed Dpp4 / mice but unchanged in SLD-fed mice and HFHC-fed Dpp4 hep/ mice, compared with controls (Figure 3N)

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Despite variable reporting, most studies report a predominance of female participants with age ranging from 31 to 60 years, with an estimated mean around 44.2 years of age

71 Non-proliferative reactive astrogliosis can vary in intensity but is isomorphic such that the astrocytes mainly retain the discrete, non-overlapping cellular domains found in the healthy grey matter but with variable degrees of cellular hypertrophy and reorganisation of their processes

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