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When these compounds were tested in INS-1 832/3 beta cells 21 with a prolonged incubation to mimic in vivo drug exposure, we found that compounds exhibiting higher internalization also had reduced maximal insulin release (Fig

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They mention significant weight loss and better blood sugar control

So - certainly we need to address our lifestyle choices - choosing to eat healthy real food - exercise - and consume good information that feeds your brain and equips you to make increasingly better decisions in your life - but also - we should strive to equip and inform people to develop practical self-awareness - emotional intelligence - resilience - emotional regulation - and skills that enable them to operate out of their prefrontal cortex on a more consistent basis (vs living in a fight or flight state - or allowing your primitive brain to make the majority of your decisions!)

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A case series published in SAGE Open Medical Case Reports examined lean soft tissue changes during GLP-1 and GLP-1/GIP receptor agonist therapy