Polonikov, 2020
The interpretation of these transcriptomic findings has been a continuing area of discussion, with some researchers viewing the broad effects as evidence of a regulatory function and others viewing them with caution given the difficulty of distinguishing direct effects from secondary consequences in such broad gene-expression landscapes
[DOI] [PMC free article] [PubMed] [Google Scholar] 80.Newsome P.N., Buchholtz K., Cusi K., Linder M., Okanoue T., Ratziu V., Sanyal A.J., Sejling A.-S., Harrison S.A
One analysis of several hundred GLP-1 studies presented compelling evidence that they improve cognitive disorders, such as Alzheimers, substance-use disorders, such as alcohol, cocaine, and cannabis addiction, and mood and anxiety disorders, such as depression and bipolar disorder
Mechanistically, dulaglutide downregulates matrix metalloproteinases (MMP-3 and MMP-13) and aggrecanases, protecting the articular extracellular matrix [50]
Mastrototaro, L
