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In the Phase 2 trial, participants on the 12 mg dose were still on a steep weight loss trajectory at 48 weeks, losing roughly 5-6 pounds per month even late in the treatment period

For first-time incretin users, tirzepatide offers several advantages: FDA approval, established safety data, pre-filled injection pens (no reconstitution needed), extensive prescriber experience, and lower side effect rates

prescription drug prices in line with, or below, those paid in other developed countries

How Long Do the Weight Loss Effects Last in Research Models Weight maintenance after cessation of GLP-1 and incretin-class compounds is an active area of investigation

Some predict it could take until 2028

6 Over the next few years, the teams at MGH and University of Copenhagen independently tested the effects of supplemental GLP-1 in people and found that infusing its biologically active form stimulated insulin secretion and lowered blood glucose