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The most significant recent finding: a May 2026 Lancet randomized controlled trial (108 patients, 26 weeks) found semaglutide 2.4 mg reduced heavy drinking days by 41.1 percentage points versus 26.4 on placebo, a statistically significant 13.7-point difference

3 Consumers inspired to manage their health through diet and exercise alone are adopting GLP-1-inspired eating patterns focused on portion control, fiber and protein intake and metabolic health without pharmaceutical intervention

doi: 10.1073/pnas.2014879117

Weeks 24 through 40 continue at a slower but steady pace (approaching 24% cumulative)

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Several peripheral and central mechanisms are believed to be involved, including altered gut hormone secretion, decrease in energy expenditure following weight loss, and psychological processes associated with the food reward system