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We aimed to update the calculator to produce probabilities more representative of the general diabetes population and to incorporate C-peptide and islet autoantibody results

The primary objective of most of the large, double-blind, randomized, placebo-controlled trials that have evaluated the cardiovascular effects of GLP-1 RAs in patients with type 2 diabetes focused on evaluating the presence of a MACE

This makes them relatively safe from a hypoglycaemia perspective, particularly when compared to sulphonylureas or insulin therapy

Low-Dose Users (25 mg to 50 mg Daily) Women prescribed spironolactone at 25 to 50 mg daily for mild hormonal acne typically have the lowest risk profile

Journal of Clinical Endocrinology & Metabolism , 108(2), 345356

This is small in any single reconstitution but adds up across an extended research protocol