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Injection technique and site rotation Proper injection technique affects both comfort and efficacy

Hypoglycemia was more frequent when semaglutide was used in combination with a sulfonylurea

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Data presented herein support the notion that prolonged exposure to GLP-1R stimulation can also induce glucose competence by a secondary mechanism involving up-regulation of glycolytic enzymes, and consequently glycolytic flux, arguably the most important stimulus-secretion coupling factor generating pathway in -cells