Insulin resistance further exacerbates this by reducing insulin sensitivity and triggering compensatory hyperinsulinemia, which promotes facilitates the conversion of testosterone to dihydrotestosterone (DHT) and suppresses LH and FSH secretion, thereby disrupting the synthesis and regulation of reproductive hormones (63, 64)
In general, angiogenesis, the formation of new vessels from pre-existing ones, consists of an orderly sequence of events triggered by growth factors secreted from the surrounding hypoxic tissue (19)
Arginine can serve as a source of cellular energy, and is involved in various pathways throughout the body
1H) at GLP-1R
10.1016/j.mce.2016.11.011 20 ChenZ.WeiH.ZhaoX.XinX.PengL.NingY.et al (2019)
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