Medical escalation protocol is initiated in the following circumstances: - A patient has had a severe side effect or adverse event - A patient has dosed or titrated inappropriately on more than one occasion - An order error has occurred regardless of patient outcome If any of the above occurs, the provider who is conducting the visit with the patient or reviewing the asynchronous message from the patient initiates the medical escalation protocol which includes: - Notifying the lead nurse practitioner or physician for the patient's state - Creating a Medical Escalation appointment for the patient -Nursing team follow up oCall patient 24 and 48 h after visit to follow up on patient progress, any in person evaluation or testing that was done oNursing team reports back to lead nurse practitioner or physician with follow-up information For any patient who presents for a visit or sends an asynchronous message to notify a provider that they have had an emergency room visit or a hospitalization, regardless of reason or diagnosis the following steps are taken: - Medical escalation protocol above is initiated -Tracking form is completed oTracking form includes all relevant patient information, GLP-1 medication, most recent dose and details regarding ER visit/hospitalization, any testing or consultations that were performed and any diagnoses made oTracking form populates to a tracking board for further review -All ER visits and hospitalizations are reviewed by a Clinical Manager and the Medical Director on the tracking board twice a day

The Glucagon Paradox For decades, Glucagon was viewed as the "enemy" of diabetics because it raises blood sugar
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And they connect the receptor to the cell internalization machinery, specifically clathrin-coated pits that pull the receptor off the cell surface and into intracellular compartments called endosomes
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Selective Agonism Rather than activating receptors fully, some experimental medications partially activate them or activate specific subtypes