Heart Protection In large-scale clinical trials like LEADER, GLP-1s were shown to lower the risk of heart attack, stroke, and cardiovascular death
As mentioned, GLP-1RAs are increasingly used in the treatment of T2MD owing to their following advantages: lowering of the levels of blood glucose, reducing body weight, improving the function of islet, and exerting potential cardiovascular benefits (206)
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Demonstrates greater fat mass reduction
Metformin and other drugs used for T2DM, like the SGLT2 inhibitors, may also reduce hyperglycemia-induced elevated endothelial ROS, independent of negative effects on complex 1, such as via inhibition of NADPH oxidase or blocking the entry of glucose into the endothelium (32, 107109, 187, 188) ( Table 2 )
