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We are all relatively familiar with the flu the coughing, sneezing, body aches, fever and restless nights
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However, the substitution of residues Glu22, Glu27 and Ala30 of GLP-1 with Gly16, Leu21 and Glu24 of exendin-4 enabled Gly2 tolerance 32
Endocrinology (1998) 139(10):442831
However, most previous reports on 18 F-labeled exendin analogs demonstrated relatively high non-specific uptakes in preclinical studies, mostly due to the labeling methodologies 16,26,27
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