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In hyperuricemia, uric acid is supersaturated in urine and forms uric acid crystals, which are transported to lysosomes by the endocytosis of renal tubular epithelial cells, destroying the lysosomal membrane and causing lysosomal rupture, in turn, resulting in renal inflammation 20

3-Oxovalproic Acid 3-Oxovalproic acid belongs to a class of organic compounds known as short-chain keto acids and their derivatives [97]

doi:10.1136/gut.20.1.37 165

These radicals subsequently react with molecular oxygen to generate phospholipid peroxyl radicals ((P)LOO), which further interact with PUFA phospholipids, extracting hydrogen atoms and producing phospholipid hydroperoxides ((P)LOOHs) [34, 36]

Side Effects Side effects commonly include hypoglycemia, nausea, nasal congestion, upper respiratory tract infection, and headache