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doi: 10.1016/j.molcel.2009.04.034 [DOI] [PMC free article] [PubMed] [Google Scholar] 43.McMillan BJ, Schnute B, Ohlenhard N, et al

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GPX4 shows antiproliferative activity

Do not restart tirzepatide if pancreatitis is confirmed unless an alternative etiology is clearly identified

MECHANISM CATEGORIES RESEARCH CONDITIONS SAFETY Side effects Limited human safety data Animal studies report wide therapeutic window Known interactions Methyl-donor depletion theoretical with chronic dosing (NNMT methylates nicotinamide using SAM) Contraindications Pregnancy/lactation (unstudied) REGULATORY STATUS FDA Not FDA-approved

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