This increase in lipids and intramyocellular lipid metabolites, a major inhibitor of insulin signaling and glucose transport, causes insulin resistance in muscle
It does not affect insulin or IGF-1 levels and is well tolerated by most patients
A few reasons for this include less physical activity (exercise), muscle loss (sarcopenia), and the normal aging of the organs
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Park J, Kim M, Kang SG et al (2015) Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway
Researchers have noted dose-dependent variability in observed effects across different animal models, underscoring that findings from one species or injury model may not generalize to others
