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However, despite promising preclinical results, the clinical translation of SIN is limited by its poor pharmacokinetic profile, including low oral bioavailability and rapid systemic clearance
Nitric oxide (NO), a reactive nitrogen species, acts as a signaling molecule that modulates vasodilation and neurotransmission [4, 5]
Both studies generally illustrate some of the advantages and problems of conducting large clinical trials
doi: 10.1590/s0100-879x2002000200009 171 MarlinRCroffMMerleSJean-Marie-FloreMRoseMMalsaSet al
Drug concentrations above 10 M might be useful for functional or mechanistic studies, but they are unlikely to be physiological relevant
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