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Moreover, we observed a pattern of gene expression consistent with the response to an iron overload, such as the upregulation of HMOX1 (encoding heme oxygenase 1) 69 , SLC40A1 (encoding ferroportin), FTH1 and FTL (encoding ferritin heavy and light chains, respectively) 70 , and metallothioneins 71 (Fig

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From the top five topics, the LLM was prompted to output the top 20 keywords associated with each topic for manual checking

This study also importantly demonstrates that metformin treatment significantly alters the metabolic profile and inflammatory secretome in rectal cancer biopsies, with minimal impact on non-cancer rectal tissue, supporting its potential as a radiosensitising agent in rectal cancer

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