Finally, the primary outcome is a surrogate measured during a short follow-up period. They are also honest: We are, therefore, not able to draw conclusions about the longer-term effects of semaglutide in this population. And they conclude that: These findings support future clinical trials to assess the efficacy of semaglutide in reducing the risk of kidney failure and cardiovascular complications in these patients. I would characterize that as a reasonable conclusion given the limitations
Significant gaps remain, particularly the lack of treatments with adequate safety and true disease-modifying potential capable of addressing key pathological drivers such as neuroinflammation, mitochondrial dysfunction, impaired proteostasis and toxic protein aggregation (Jiang et al., 2025)
Sciatica Clinic
During this visit, your provider will also ask you about the weight reduction methods youve tried in the past
Proper hydration should be maintained by increasing water intake as needed, likely a minimum of 64oz per day
In May 2022, Tirzepatide, marketed under the brand name Mounjaro, was approved by the U.S